Hongzheng Dai
PhD
Associate Clinical Director, NGS/Molecular
Dr. Hongzheng Dai serves as the Associate Clinical Director of NGS/ Molecular at Baylor Genetics. In his current role, he explores possible diagnoses for genetic disorders through the analysis and review of genetics and genomics data from various research projects and clinical genetic services. In addition to his role at BG, Dr. Dai is an Assistant Professor at Baylor College of Medicine.
Dr. Dai received his doctorate in genetics from the University of Chicago and completed his postdoctoral trainings at Rockefeller and Johns Hopkins University. Three years after joining the Medical Genetics Laboratories at BCM, he obtained his ABMGG clinical molecular genetics and genomics training at Baylor College of Medicine.
Dr. Dai has abundant experience in basic research and clinical genetics. In addition, he has been involved in multiple research and development projects in the diagnostic lab, inter-institutional consortium teams, and peer-review publications.
Position
Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States
Associate Clinical Director
NGS/Molecular
Baylor Genetics
Houston, TX, United States
Education
PhD from University of Chicago
Chicago, IL, United States
MA from Tsinghua University
Beijing, China
BA from Tsinghua University
Beijing, China
Certifications
MB
American Society for Clinical Pathology
Board Eligible in Clinical Molecular Genetics and Genomics
American Board of Medical Genetics and Genomics
Publications
Rapid Whole Genome Sequencing (rWGS) As A First-Tier Test For Critically Ill Children With Suspected Genetic Etiology
Dai, H. Platform Presentation at ASHG 2022.
Use of exome sequencing for infants in intensive care units: Ascertainment of severe single-gene disorders and effect on medical management
Meng, L., Pammi, M., Saronwala, A., Magoulas, P., Ghazi, A. R., Vetrini, F., Zhang, J., He, W., Dharmadhikari, A. V., Qu, C., Ward, P., Braxton, A., Narayanan, S., Ge, X., Tokita, M. J., Santiago-Sim, T., Dai, H., Chiang, T., Smith, H., Azamian, M. S., … Lalani, S. R. (2017). Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management. JAMA Pediatrics, 171(12), e173438. https://doi.org/10.1001/jamapediatrics.2017.3438. PMID: 28973083.
Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected mendelian disorder
Normand, E. A., Braxton, A., Nassef, S., Ward, P. A., Vetrini, F., He, W., Patel, V., Qu, C., Westerfield, L. E., Stover, S., Dharmadhikari, A. V., Muzny, D. M., Gibbs, R. A., Dai, H., Meng, L., Wang, X., Xiao, R., Liu, P., Bi, W., Xia, F., … Yang, Y. (2018). Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder. Genome Medicine, 10(1), 74. https://doi.org/10.1186/s13073-018-0582-x. PMID: 30266093.
Contribution of uniparental disomy in a clinical trio exome cohort of 2,675 patients
Contribution of uniparental disomy in a clinical trio exome cohort of 2675 patients. Wang L, Liu P, Bi W, Sim T, Wang X, Walkiewicz M, Leduc MS, Meng L, Xia F, Eng CM, Yang Y, Yuan B, Dai H. Mol Genet Genomic Med. 2021 Sep 29; e1792. PMID: 34587367.
Sequencing individual genomes with recurrent deletions reveals allelic architecture and disease loci for autosomal recessive traits
Yuan, B., Schulze, K. V., Assia Batzir, N., Sinson, J., Dai, H., Zhu, W., Bocanegra, F., Fong, C. T., Holder, J., Nguyen, J., Schaaf, C. P., Yang, Y., Bi, W., Eng, C., Shaw, C., Lupski, J. R., & Liu, P. (2022). Sequencing individual genomes with recurrent genomic disorder deletions: an approach to characterize genes for autosomal recessive rare disease traits. Genome Medicine, 14(1), 113. PMID: 36180924.
Reanalysis of Clinical Exome Sequencing Data
Reanalysis of Clinical Exome Sequencing Data. Liu P, Meng L, Normand EA, Xia F, Song X, Ghazi A, Rosenfeld J, Magoulas PL, Braxton A, Ward P, Dai H, Yuan B, Bi W, Xiao R, Wang X, Chiang T, Vetrini F, He W, Cheng H, Dong J, Gijavanekar C, Benke PJ, Bernstein JA, Eble T, Eroglu Y, Erwin D, Escobar L, Gibson JB, Gripp K, Kleppe S, Koenig MK, Lewis AM, Natowicz M, Mancias P, Minor L, Scaglia F, Schaaf CP, Streff H, Vernon H, Uhles CL, Zackai EH, Wu N, Sutton VR, Beaudet AL, Muzny D, Gibbs RA, Posey JE, Lalani S, Shaw C, Eng CM, Lupski JR, Yang Y. N Engl J Med. 2019 Jun 20; 380(25):2478-2480. PMID: 31216405
A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene
Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ. A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene. J Mol Diagn. 2015 Sep;17(5):545-53. doi: 10.1016/j.jmoldx. 2015.04.001. [with Press Release] PMID: 26320870
Molecular and clinical spectra of FBXL4 deficiency
El-Hattab AW, Dai H, Almannai M, Wang J et al. (2017) Molecular and clinical spectra of FBXL4 Hum Mutat. 38:1649-1659. PMID: 28940506
FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome.
Dai H, Zhang W, El-hattab AW, Ficicioglu C, Shinawi M, Lines M, Schulze A, McNutt M, Gotway G, Tian X, Chen S, Wang J, Craigen WJ, Wong LJ. (2017) FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome. Clin Genet. 91:634-39. PMID: 27743463
MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects
El-Hattab AW, Wang J, Dai H et al, (2018) MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects. Hum Mutat (In press)
FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome
Almannai M, Dai H, El-Hattab AW, Wong LJC. (2017) FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mefford HC, Stephens K, Amemiya A, Ledbetter N, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2017. PMID: 28383868
Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
Li Z*, Dai H*, Martos S, Xu B, Gao Y, Li T, Zhu GJ, Schones D & Wang ZB. (2015) Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biology. 16: 115 (*: contributed equally). PMID: 26032981
Transcriptional silencing of Arabidopsis endogenes by single-stranded RNAs targeting the promoter region.
Deng S*, Dai H*, Arenas C, Wang H, Niu QW, Chua NH (2014) Transcriptional silencing of Arabidopsis endogenes by single-stranded RNAs targeting the promoter region. Plant Cell Physiol. 55:823-33. (*: contributed equally). PMID: 24492259
Hongzheng Dai
PhD
Associate Clinical Director, NGS/Molecular
Dr. Hongzheng Dai serves as the Associate Clinical Director of NGS/ Molecular at Baylor Genetics. In his current role, he explores possible diagnoses for genetic disorders through the analysis and review of genetics and genomics data from various research projects and clinical genetic services. In addition to his role at BG, Dr. Dai is an Assistant Professor at Baylor College of Medicine.
Dr. Dai received his doctorate in genetics from the University of Chicago and completed his postdoctoral trainings at Rockefeller and Johns Hopkins University. Three years after joining the Medical Genetics Laboratories at BCM, he obtained his ABMGG clinical molecular genetics and genomics training at Baylor College of Medicine.
Dr. Dai has abundant experience in basic research and clinical genetics. In addition, he has been involved in multiple research and development projects in the diagnostic lab, inter-institutional consortium teams, and peer-review publications.
Position
Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States
Associate Clinical Director
NGS/Molecular
Baylor Genetics
Houston, TX, United States
Education
PhD from University of Chicago
Chicago, IL, United States
MA from Tsinghua University
Beijing, China
BA from Tsinghua University
Beijing, China
Certifications
MB
American Society for Clinical Pathology
Board Eligible in Clinical Molecular Genetics and Genomics
American Board of Medical Genetics and Genomics
Publications
Rapid Whole Genome Sequencing (rWGS) As A First-Tier Test For Critically Ill Children With Suspected Genetic Etiology
Dai, H. Platform Presentation at ASHG 2022.
Use of exome sequencing for infants in intensive care units: Ascertainment of severe single-gene disorders and effect on medical management
Meng, L., Pammi, M., Saronwala, A., Magoulas, P., Ghazi, A. R., Vetrini, F., Zhang, J., He, W., Dharmadhikari, A. V., Qu, C., Ward, P., Braxton, A., Narayanan, S., Ge, X., Tokita, M. J., Santiago-Sim, T., Dai, H., Chiang, T., Smith, H., Azamian, M. S., … Lalani, S. R. (2017). Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management. JAMA Pediatrics, 171(12), e173438. https://doi.org/10.1001/jamapediatrics.2017.3438. PMID: 28973083.
Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected mendelian disorder
Normand, E. A., Braxton, A., Nassef, S., Ward, P. A., Vetrini, F., He, W., Patel, V., Qu, C., Westerfield, L. E., Stover, S., Dharmadhikari, A. V., Muzny, D. M., Gibbs, R. A., Dai, H., Meng, L., Wang, X., Xiao, R., Liu, P., Bi, W., Xia, F., … Yang, Y. (2018). Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder. Genome Medicine, 10(1), 74. https://doi.org/10.1186/s13073-018-0582-x. PMID: 30266093.
Contribution of uniparental disomy in a clinical trio exome cohort of 2,675 patients
Contribution of uniparental disomy in a clinical trio exome cohort of 2675 patients. Wang L, Liu P, Bi W, Sim T, Wang X, Walkiewicz M, Leduc MS, Meng L, Xia F, Eng CM, Yang Y, Yuan B, Dai H. Mol Genet Genomic Med. 2021 Sep 29; e1792. PMID: 34587367.
Sequencing individual genomes with recurrent deletions reveals allelic architecture and disease loci for autosomal recessive traits
Yuan, B., Schulze, K. V., Assia Batzir, N., Sinson, J., Dai, H., Zhu, W., Bocanegra, F., Fong, C. T., Holder, J., Nguyen, J., Schaaf, C. P., Yang, Y., Bi, W., Eng, C., Shaw, C., Lupski, J. R., & Liu, P. (2022). Sequencing individual genomes with recurrent genomic disorder deletions: an approach to characterize genes for autosomal recessive rare disease traits. Genome Medicine, 14(1), 113. PMID: 36180924.
Reanalysis of Clinical Exome Sequencing Data
Reanalysis of Clinical Exome Sequencing Data. Liu P, Meng L, Normand EA, Xia F, Song X, Ghazi A, Rosenfeld J, Magoulas PL, Braxton A, Ward P, Dai H, Yuan B, Bi W, Xiao R, Wang X, Chiang T, Vetrini F, He W, Cheng H, Dong J, Gijavanekar C, Benke PJ, Bernstein JA, Eble T, Eroglu Y, Erwin D, Escobar L, Gibson JB, Gripp K, Kleppe S, Koenig MK, Lewis AM, Natowicz M, Mancias P, Minor L, Scaglia F, Schaaf CP, Streff H, Vernon H, Uhles CL, Zackai EH, Wu N, Sutton VR, Beaudet AL, Muzny D, Gibbs RA, Posey JE, Lalani S, Shaw C, Eng CM, Lupski JR, Yang Y. N Engl J Med. 2019 Jun 20; 380(25):2478-2480. PMID: 31216405
A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene
Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ. A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene. J Mol Diagn. 2015 Sep;17(5):545-53. doi: 10.1016/j.jmoldx. 2015.04.001. [with Press Release] PMID: 26320870
Molecular and clinical spectra of FBXL4 deficiency
El-Hattab AW, Dai H, Almannai M, Wang J et al. (2017) Molecular and clinical spectra of FBXL4 Hum Mutat. 38:1649-1659. PMID: 28940506
FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome.
Dai H, Zhang W, El-hattab AW, Ficicioglu C, Shinawi M, Lines M, Schulze A, McNutt M, Gotway G, Tian X, Chen S, Wang J, Craigen WJ, Wong LJ. (2017) FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome. Clin Genet. 91:634-39. PMID: 27743463
MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects
El-Hattab AW, Wang J, Dai H et al, (2018) MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects. Hum Mutat (In press)
FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome
Almannai M, Dai H, El-Hattab AW, Wong LJC. (2017) FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mefford HC, Stephens K, Amemiya A, Ledbetter N, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2017. PMID: 28383868
Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
Li Z*, Dai H*, Martos S, Xu B, Gao Y, Li T, Zhu GJ, Schones D & Wang ZB. (2015) Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biology. 16: 115 (*: contributed equally). PMID: 26032981
Transcriptional silencing of Arabidopsis endogenes by single-stranded RNAs targeting the promoter region.
Deng S*, Dai H*, Arenas C, Wang H, Niu QW, Chua NH (2014) Transcriptional silencing of Arabidopsis endogenes by single-stranded RNAs targeting the promoter region. Plant Cell Physiol. 55:823-33. (*: contributed equally). PMID: 24492259